THROMBOSIS AND HEMOSTASIS Diminished contact-dependent reinforcement of Syk activation underlies impaired thrombus growth in mice lacking Semaphorin 4D

1Department of Medicine, University of Pennsylvania School of Medicine, Philadelphia, PA; 2Cyrus Tang Hematology Center, Jiangsu Institute of Hematology, The First Affiliated Hospital, Soochow University, Suzhou, China; 3Key Laboratory of Thrombosis and Hemostasis of Ministry of Health, The First Affiliated Hospital of Soochow University, Suzhou, China; 4Department of Bioengineering, University of Pennsylvania School of Medicine, Philadelphia, PA; 5Department of Chemical Engineering, Colorado School of Mines, University of Colorado, Denver, CO; 6Departments of Immunopathology and Molecular Immunology, Research Institute for Microbial Diseases, Osaka University, Osaka, Japan; 7Department of Chemical and Biomolecular Engineering, University of Pennsylvania School of Medicine, Philadelphia, PA; and 8Department of Pharmacology, University of Pennsylvania School of Medicine, Philadelphia, PA